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wild type male c57bl 6j mice  (Jackson Laboratory)

 
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    Jackson Laboratory wild type male c57bl 6j mice
    Wild Type Male C57bl 6j Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/wild+type+male+c57bl+6j+mice/pm42284144-334-2-6?v=Jackson+Laboratory
    Average 86 stars, based on 1 article reviews
    wild type male c57bl 6j mice - by Bioz Stars, 2026-07
    86/100 stars

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    (A) Experimental design for elastase administration and lung RNA sequencing. Eleven-week-old <t>male</t> <t>C57BL/6J</t> mice received intratracheal elastase at 2 mg/kg, and lungs were collected at day 1, week 1, and week 2. (B) Principal component analysis of lung bulk RNA-sequencing data from control and elastase-treated mice. (C) Overview of the CIBERSORTx workflow. A signature matrix generated from mouse lung single-cell RNA-sequencing data (GSE168299) was applied to bulk lung RNA-sequencing profiles from control and elastase-treated mice. (D) Estimated proportions of lung cell-type-associated signatures inferred by CIBERSORTx. (E) Inferred aerocyte capillary endothelial (aCap) and general capillary endothelial (gCap) fractions. (F) Lung expression of Apln and apelin receptor/APJ-associated transcript in bulk RNA-sequencing data. (G) Lung apelin protein levels measured by enzyme-linked immunosorbent assay. Data are means ± SEM; n = 3–6 mice per group. P values were determined by one-way ANOVA with Dunnett’s multiple-comparisons test. * P < 0.05, ** P < 0.01, *** P < 0.001.
    Male C57bl 6j Wild Type Mice, supplied by Charles River Laboratories, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    (A) Experimental design for elastase administration and lung RNA sequencing. Eleven-week-old male C57BL/6J mice received intratracheal elastase at 2 mg/kg, and lungs were collected at day 1, week 1, and week 2. (B) Principal component analysis of lung bulk RNA-sequencing data from control and elastase-treated mice. (C) Overview of the CIBERSORTx workflow. A signature matrix generated from mouse lung single-cell RNA-sequencing data (GSE168299) was applied to bulk lung RNA-sequencing profiles from control and elastase-treated mice. (D) Estimated proportions of lung cell-type-associated signatures inferred by CIBERSORTx. (E) Inferred aerocyte capillary endothelial (aCap) and general capillary endothelial (gCap) fractions. (F) Lung expression of Apln and apelin receptor/APJ-associated transcript in bulk RNA-sequencing data. (G) Lung apelin protein levels measured by enzyme-linked immunosorbent assay. Data are means ± SEM; n = 3–6 mice per group. P values were determined by one-way ANOVA with Dunnett’s multiple-comparisons test. * P < 0.05, ** P < 0.01, *** P < 0.001.

    Journal: bioRxiv

    Article Title: Early apelin receptor activation attenuates elastase-induced emphysema and preserves endothelial apelin receptor signaling in mice

    doi: 10.64898/2026.05.12.724387

    Figure Lengend Snippet: (A) Experimental design for elastase administration and lung RNA sequencing. Eleven-week-old male C57BL/6J mice received intratracheal elastase at 2 mg/kg, and lungs were collected at day 1, week 1, and week 2. (B) Principal component analysis of lung bulk RNA-sequencing data from control and elastase-treated mice. (C) Overview of the CIBERSORTx workflow. A signature matrix generated from mouse lung single-cell RNA-sequencing data (GSE168299) was applied to bulk lung RNA-sequencing profiles from control and elastase-treated mice. (D) Estimated proportions of lung cell-type-associated signatures inferred by CIBERSORTx. (E) Inferred aerocyte capillary endothelial (aCap) and general capillary endothelial (gCap) fractions. (F) Lung expression of Apln and apelin receptor/APJ-associated transcript in bulk RNA-sequencing data. (G) Lung apelin protein levels measured by enzyme-linked immunosorbent assay. Data are means ± SEM; n = 3–6 mice per group. P values were determined by one-way ANOVA with Dunnett’s multiple-comparisons test. * P < 0.05, ** P < 0.01, *** P < 0.001.

    Article Snippet: Male C57BL/6J wild-type mice were obtained from Charles River Laboratories Japan (Atsugi, Japan).

    Techniques: RNA Sequencing, Control, Generated, Single Cell, Expressing, Enzyme-linked Immunosorbent Assay

    (A) Overview of CIBERSORTx analysis using a mouse lung single-cell RNA-sequencing reference dataset and bulk lung RNA-sequencing data from control and C57BL/6J-βENaC-transgenic mice. (B) Estimated proportions of lung cell-type-associated signatures inferred by CIBERSORTx. (C) Inferred aCap and gCap fractions. (D) Lung expression of Apln and apelin receptor/APJ-associated transcript in bulk RNA-sequencing data. (E) Lung apelin protein levels measured by enzyme-linked immunosorbent assay. Data are means ± SEM; n = 3–6 mice per group. P values were determined by two-tailed Student’s t -test. ** P < 0.01.

    Journal: bioRxiv

    Article Title: Early apelin receptor activation attenuates elastase-induced emphysema and preserves endothelial apelin receptor signaling in mice

    doi: 10.64898/2026.05.12.724387

    Figure Lengend Snippet: (A) Overview of CIBERSORTx analysis using a mouse lung single-cell RNA-sequencing reference dataset and bulk lung RNA-sequencing data from control and C57BL/6J-βENaC-transgenic mice. (B) Estimated proportions of lung cell-type-associated signatures inferred by CIBERSORTx. (C) Inferred aCap and gCap fractions. (D) Lung expression of Apln and apelin receptor/APJ-associated transcript in bulk RNA-sequencing data. (E) Lung apelin protein levels measured by enzyme-linked immunosorbent assay. Data are means ± SEM; n = 3–6 mice per group. P values were determined by two-tailed Student’s t -test. ** P < 0.01.

    Article Snippet: Male C57BL/6J wild-type mice were obtained from Charles River Laboratories Japan (Atsugi, Japan).

    Techniques: Single Cell, RNA Sequencing, Control, Transgenic Assay, Expressing, Enzyme-linked Immunosorbent Assay, Two Tailed Test